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Digital platform ecosystems have redefined firm boundaries, transforming competition into coordinated networks of interdependent actors who jointly generate value through platform participation. This conceptual article addresses a critical gap in the literature by developing an integrative framework that explains how firms can strategically engage in these ecosystems while managing complex interdependencies with platform leaders and complementors. By synthesizing foundational insights on ecosystem theory, platform meta-organizations, complementor engagement, governance mechanisms, and value co-creation, we identify the need for a holistic model that goes beyond isolated strategies. We introduce the strategic interdependence orchestration framework (SIOF), a novel architecture comprising five interconnected components—ecosystem role positioning, interdependence mapping, governance mechanism deployment, complementor coordination protocols, and value co-creation pathways—supported by adaptive feedback loops. The SIOF positions ecosystem participation as a core competitive strategy, enabling firms to convert interdependence risks into sustained value advantages within platform-centered networks. By theorizing the relational flows of coordination, governance, and learning, this framework advances platform strategy research and offers actionable guidance for firms navigating digital ecosystems. A detailed conceptual diagram illustrates the architecture, highlighting dynamic relationships and feedback mechanisms essential for long-term ecosystem success.

Digital business ecosystems powered by platform networks are defined by profound interdependence among participating firms, where success depends on coordinated actions across autonomous actors rather than hierarchical control. Traditional management approaches fall short in these settings, as firms must simultaneously manage complementarities, network effects, and coopetition while enabling value co-creation. This manuscript introduces the Strategic Coordination of Interdependence in Platform Ecosystems (SCIPE) framework. This novel multi-layer conceptual model integrates actor roles, interdependence structures, coordination mechanisms, non-hierarchical governance, and adaptive feedback loops. Synthesized from peer-reviewed publications spanning strategic management, information systems, and innovation journals, the framework addresses critical gaps in the literature on ecosystem orchestration and governance. By delineating how platform owners and complementors can strategically align without formal authority, the SCIPE Framework advances theory on interdependence management and offers practical guidance for sustaining ecosystem vitality. The model emphasizes dynamic adaptation through feedback, balancing cooperation and competition to enhance resilience and competitiveness in digital markets. Theoretical contributions bridge fragmented streams on platform dynamics, while managerial implications equip leaders with actionable layers for coordination. Future extensions include cross-industry validation and longitudinal studies of adaptation processes.